Ribosomal protein L13



Ribosomal protein L13 (RPL13) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL13 is one of the early assembly proteins of the large subunit. The images at the left and at the right correspond to one representative RPL13, i.e. the crystal structure of Ribosomal protein L13 from Pyrococcus horikoshii (1j3a).

RPL13
1j3a – RPL13P – Pyrococcus horikoshii

L13 in 50S subunit+RNA
2xg0, 2xg2, 3kir, 3kit, 3kiw, 3kiy – TtRPL13 in 50S subunit+RNA fragments - Thermus thermophilus

2x9s, 2x9u, 3kni, 3knk, 3knm, 3kno, 2wrj, 2wrl, 2wro, 2wrr, 3hux, 3huz, 2wh2, 2wh4, 2wdi, 2wdj, 2wdl, 2wdn, 1vsp, 2v47, 2v49, 1vsa, 2hgj, 2hgq, 2hgu, 2j01, 2j03, 1yl3, 3mrz, 3ms1, 3i8f, 3i8i, 3i9c, 3i9e, 3f1f, 3f1h, 3d5b, 3d5d, 2b66, 2b9n, 2b9p, 1giy, 2xqe - TtRPL13 in 50S subunit+5S RRNA+23S RRNA

3fin - TtRPL13 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM

2wwq – EcRPL13 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – Escherichia coli

3i1n, 3i1p, 3i1r, 3i1t, 3i20, 3i22, 3e1b, 3e1d, 3df2, 3df4, 2vhn, 2qov, 2qox, 2i2t, 2i2v, 1vs6, 1vs8, 2aw4, 2awb, 2ofd, 3og0 - EcRPL13 in 50S subunit+5S RRNA+23S RRNA

3fik, 2gya, 2gyc, 3bbx, 1p85, 1p86 - EcRPL13 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM

3kcr - EcRPL13 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase

3bbo - RPL13 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach

2zjq, 2zjr - DrRPL13 in 50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans

1kqs, 1qvg - HmRPL13P in 50S subunit+5S RRNA+23S RRNA+CCA - Haloarcula marismortui

1jj2, 1ffk, 3cc2, 2qa4, 1s72 - HmRPL13P in 50S subunit+5S RRNA+23S RRNA

3cc7, 3cce, 3ccj, 3ccl, 3ccm, 3ccq, 3ccr, 3ccs, 3ccu, 3ccv - HmRPL13P in 50S subunit+5S RRNA+23S RRNA (mutant)

1yj9 - HmRPL13P in 50S subunit (L22 mutant)+5S RRNA+23S RRNA

1vq4, 1vq5, 1vq7, 1vql, 1vqm, 1vqp - HmRPL13P in 50S subunit+5S RRNA+23S RRNA+transition state analog

1vq6, 1vqk, 1vqn - HmRPL13P in 50S subunit+5S RRNA+23S RRNA+ c-hpmn+CCA-Phe-caproic acid-biotin

1q86 - HmRPL13P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-caproic acid-biotin

1vqo - HmRPL13P in 50S subunit+5S RRNA+23S RRNA+ CCPMN

1qvf - HmRPL13P in 50S subunit+5S RRNA+23S RRNA + deacylated tRNA minihelix

3iy9 – RPL13 in 50S subunit – Leishmania taretolae

L13 in 50S subunit + antibiotics
3cxc – RPL13 in 50S subunit+5S RRNA+23S RRNA +oxazolidinone inhibitor – Halobacterium marismortui

3dll - DrRPL13 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+oxazolidinone inhibitor

2zjp - DrRPL13 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+nosiheptide

3cf5 - DrRPL13 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiostrepton

1xbp - DrRPL13 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+thiamulin

1sm1 - DrRPL13 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+quinupristin+dalfopristin

1nwx - DrRPL13 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+ABT-773

1nwy - DrRPL13 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+azithromycin

2qam, 2qao, 2qoz, 2qp1 - EcRPL13 in 50S subunit+5S RRNA+23S RRNA+neomycin

2qba, 2qbc - EcRPL13 in 50S subunit+5S RRNA+23S RRNA+gentamicin

3ofc – EcRPL13 in 50S subunit+5S RRNA+23S RRNA+chloramphenicol

3ofz – EcRPL13 in 50S subunit+5S RRNA+23S RRNA+clindamycin

3ofq, 3ofr – EcRPL13 in 50S subunit+5S RRNA+23S RRNA+erythromycin

1vt2, 3orb – EcRPL13 in 50S subunit+5S RRNA+23S RRNA+CEM-101

1k73, 1kc8, 1k8a, 1k9m, 1kd1, 1m1k, 3i55, 3i56, 3g4s, 3g6e, 3g71, 2qex, 3cpw, 3cc4, 3cd6, 2otj, 2otl, 1yit, 1q7y, 1q81, 1q82, 1n8r, 1nji - HmRPL13P in 50S subunit+5S RRNA+23S RRNA+antibiotic

1yhq, 1yi2, 1yij, 1yjn, 1yjw - HmRPL13P in 50S subunit+5S RRNA+23S RRNA (mutant)+antibiotic

1m90, 3cma, 3cme, 1vq8, 1vq9 - HmRPL13P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin

3oh5, 3oh7 - TtRPL13 in 50S subunit+5S RRNA+23S RRNA + chloramphenicol

3ohj, 3ohk - TtRPL13 in 50S subunit+5S RRNA+23S RRNA +erythromycin

3ohz, 3oi1 - TtRPL13 in 50S subunit+5S RRNA+23S RRNA +azithromycin

3oi3, 3oi5 - TtRPL13 in 50S subunit+5S RRNA+23S RRNA +telithromycin

L13 in 60S subunit
1s1i - yRPL13 in 40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast

L13 in large + small ribosomal subunit
1ml5 - EcRPL13 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM

2zkr - RPL13 in 60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM – dog

L13 in 50S subunit + ribosome releasing factor (RRF)
2qbe, 2qbg, 2qbi, 2qbk, 2z4l, 2z4n - EcRPL13 in 50S subunit+5S RRNA+23S RRNA+RRF

2rdo - EcRPL13 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM

L13 in 50S subunit + various proteins
2vhm - EcRPL13 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix

2j28 - EcRPL13 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM

1vor, 1vou, 1vow, 1voy, 1vp0, 1pnu, 1pny - EcRPL13 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc

1nkw - DrRPL13 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc

1w2b - HmRPL13P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal

L13 in the 39S mitochondrial subunit
2ftc – RPL13 in 39S subunit+16S RRNA - bovine